Sermorelin5mg–10mg
$75Lyophilized Sermorelin supplied as a research reference standard.
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Supplied to qualified labs and institutional buyers. Institutional use & eligibility
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Characteristics
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
|---|---|
| CAS Number | 86168-78-7 |
| Molar Mass | 3357.88 g/mol |
| Amino Acid Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ |
| Synonyms | GHRH (1-29), GRF (1-29) NH₂, Sermorelin acetate |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in water and aqueous laboratory solvent |
| Organoleptic Profile | White to off-white lyophilized powder; odorless |
| Storage Conditions | Store lyophilized at -20°C; reconstituted solution stable at 2-8°C for up to 14 days |
| Composition | Lyophilized sermorelin acetate |
How is Sermorelin used in research?
Sermorelin is a 29-amino acid synthetic peptide analog of GHRH(1-29), supplied as a lyophilized reference standard for in-vitro receptor-activation assays, structural analysis, and analytical method development. The 29-residue sequence corresponds to the N-terminal fragment of endogenous growth hormone-releasing hormone and is the minimal sequence that retains full binding activity at the GHRH receptor.
At the molecular level, sermorelin is studied as a GHRH-receptor ligand in in-vitro receptor-binding assays conducted in anterior pituitary somatotroph cell-culture systems. Binding activates the Gs-adenylyl cyclase-cAMP-PKA signaling cascade, which is tracked with standard biochemical readouts (cAMP accumulation assays, PKA-substrate phosphorylation panels). Supplied for laboratory characterization only. Not for use in any living organism.
Researchers use sermorelin as a reference compound in analytical method development - HPLC and mass-spectrometry identity assays, purity-profile characterization, and comparability work against newer GHRH analogs. In-vitro receptor-activation assays and structural analysis (circular dichroism, NMR conformational studies) represent the principal laboratory use cases for this research standard.
Areas of Study
In-Vitro Receptor-Activation Assays
Used as a GHRH-receptor reference ligand in cAMP accumulation assays on cultured somatotroph cell lines and recombinant GHRH-R expression systems.
Structural Analysis
Characterized by circular dichroism, NMR, and mass spectrometry to profile secondary-structure content and counter-ion composition.
Analytical Method Development
Applied as an identity and purity reference standard in HPLC assay development and comparability testing against newer GHRH analogs.
Receptor-Binding Studies
Employed in competitive binding assays to profile GHRH-R affinity of novel analogs and truncation mutants in cell-culture systems.
Reference Compound Use
Serves as a historical reference GHRH(1-29) standard for comparability and analytical characterization in laboratory workflows.
References
- [1]Walker RF. (2006). Sermorelin: a review of GHRH (1-29) as a research tool in growth hormone axis physiology. Clinical Interventions in Aging, 1(4), 307-308.
- [2]Gaylinn BD, Thorner MO. (2001). GHRH receptors, secretagogue receptors, and growth hormone secretion. Growth Hormone & IGF Research, 11(Suppl A), S35-S38.
- [3]Alba M, Fintini D, Bowers CY, et al. (2005). Effects of GHRH and GHRP-6, alone and in combination, on GH secretion in aged rats. Journal of Endocrinology, 185(3), 543-551.
Disclaimer: Information provided for research reference only; not medical advice. Sold strictly for in-vitro research use.
Certificate of Analysis
Third-party verified
Every batch of Sermorelin is independently tested by an A2LA-accredited (ISO 17025:2017) laboratory using HPLC-UV/VIS for purity and identity, with a batch-specific lot number. Results are published publicly.
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Asked
Questions
Everything on purity, paperwork, shipping and the research-use-only terms. Still stuck? Read the full FAQ.
What does research use only mean?
Every compound we supply is an analytical-grade biochemical reference standard intended strictly for in vitro laboratory research. These products are not for human consumption. They are not a drug, food, supplement, or medical device, have not been evaluated by the U.S. Food and Drug Administration, and are not for human or veterinary use, diagnostic use, or therapeutic use.
Who do you supply?
We supply qualified researchers and institutional buyers: academic institutions, biotech companies, contract research organizations (CROs), and analytical laboratories. Purchasers must be at least 21 years of age and confirm that material is for in vitro laboratory research only.
How is purity verified?
Every lot is assayed by HPLC at an independent, accredited third-party laboratory. We publish the resulting Certificate of Analysis and link it to the lot number printed on the vial.
Where do I find the Certificate of Analysis?
Every lot has a public, batch-linked COA. Browse them all on the COA page, or open any product page and use the COA tab for that specific compound.
How quickly do orders ship?
Orders placed before 2PM EST ship the same business day. Shipments are cold-packed where required and fully tracked.
Do you ship internationally?
We currently ship within the United States. Requests from institutional buyers outside the US are handled case by case, so contact us before ordering.
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